In fusion technology MUSCLE3 helps coupling different codes, even if written in different languages, into a single workflow, while each code component maintains its internal state throughout. The aim of the technology is to develop generic methods and efficient algorithms for uncertainty quantification and sensitivity analysis for multiscale modelling and simulation. In addition, it implements these as high-quality modules of the publicly available Multiscale Modelling and Simulation Framework. This, in return, validates, verifies, and sensitively analyzes multiscale data. The applications of such a technology can tackle challenging multi data analysis in various sectors such as climate, energy, health, etc. This sensitivity analysis of multiscale workflows reduces the number of varied inputs and therefore cut down the sample size and cost.