Remote handling of heavy in-vessel components inside nuclear fusion reactors requires the use of large robotic systems that are subject to large deformation, either induced by the geometric configuration of their mechanical structure or by the heavy payloads they usually transport. In this context, the modelling and vibration control of flexible mechanical systems aims at developing simulation tools to accurately predict the motion of flexible mechanical systems for analysis, planning and control purpose, crucial for reducing the need for full-scale mock-ups of remote operations. The approach already validated in the fusion sector can be extended to other application domains outside fusion where accurate modelling or remote handling systems is required.